Potential of Bioactive Compounds of Arenga Vinegar as Traditional Medicine Through Reverse Docking Techniques
Abstract
Background: Arenga vinegar (Arenga pinnata) has been trusted by the indigenous people of Kampung Kuta as traditional medicine, one of which is used as a diabetes medicine. For this reason, the aim of this study is to examine the bioactive compounds contained in arenga vinegar, namely acetic acid, which is predicted to be scientifically proven using reverse docking techniques. Methods: This research is descriptive qualitative research, by interpreting the data obtained from databases and software. Results: There is a binding pose between acetic acid and the sucrase-isomaltase enzyme, the lowest binding affinity value is -3.2 kcal/mol, and the binding site occurs hydrophobic interactions with the amino acids Trp327 (A), Asp355 (A), Ile392 (A), Trp470 (A), Phe604 (A), His629 (A), Trp586 (A) as well as hydrogen bonding to the amino acid Asp(472)A. Conclusions: The acetic acid-binding pose binds well to the sucrase-isomaltase enzyme so that the binding affinity value appears even though the value is not too low and the binding site occurs, this can be used as proof of the belief of the indigenous people of Kampung Kuta, namely the treatment of arenga vinegar as a diabetes drug, especially as a level control blood sugar.
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References
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Baharuddin, Syahidah, & Yatni, N. (2009). Penentuan Mutu Cuka Nira Aren (Arenga pinnata) Berdasarkan SNI 01-4371-1996. Perennial, 5(1), 31. https://doi.org/10.24259/perennial.v5i1.187
Beheshti, Z., Chan, Y. H., Nia, H. S., Hajihosseini, F., Nazari, R., Shaabani, M., & Omran, M. T. S. (2012). Influence of Apple Cider Vinegar on Blood Lipids. Life Science Journal, 9(4), 2431–2440.
Casem, M. L. (2016). Case Studies in Cell Biology. https://doi.org/10.1016/B978-0-12-801394-6/00009-9
Estela, C. (2019). Blood Glucose Levels. Blood Glucose Levels, 3(2). https://doi.org/10.5772/intechopen.73823
Ferdinal, F. (2005). Enzim"¯: Peranan Biologik, Transformasi Ganas dan Transduksi Sinyal. 11.
Hairunnisa, H. (2019). Sulitnya Menemukan Obat Baru di Indonesia. Majalah Farmasetika, 4(1), 16. https://doi.org/10.24198/farmasetika.v4i1.22517
Hardoyo, Tjahjono, A. E., Primarini, D., Hartono, & Musa. (2017). Kondisi Optimum Fermentasi Asam Asetat Menggunakan Acetobacter Aceti B166. J. Sains MIPA, 13(1), 17–20.
Johnston, C. S., & Buller, A. J. (2005). Vinegar and Peanut Products as Complementary Foods to Reduce Postprandial Glycemia. Journal of the American Dietetic Association, 105(12), 1939–1942. https://doi.org/10.1016/j.jada.2005.07.012
Kemp, M. L. (2013). Encyclopedia of Systems Biology (W. Dubitzky, O. Wolkenhauer, K.-H. Cho, & H. Yokota (eds.)). https://doi.org/10.1007/978-1-4419-9863-7_323
Kharkar, P. S., Warrier, S., & Gaud, R. S. (2014). Reverse Docking: A Powerful Tool for Drug Repositioning and Drug Rescue. Future Medicinal Chemistry, 6(3), 333–342. https://doi.org/10.4155/fmc.13.207
Lee, B. H., Quezada-Calvillo, R., Nichols, B. L., Rose, D. R., & Hamaker, B. R. (2012). Inhibition of Maltase-glucoamylase Activity to Hydrolyse α-1,4 Linkages by the Presence of Undigested Sucrose. Journal of Pediatric Gastroenterology and Nutrition, 55(SUPPL.2), 45–47. https://doi.org/10.1097/01.mpg.0000421415.95751.f7
Mitrou, P., Petsiou, E., Papakonstantinou, E., Maratou, E., Lambadiari, V., Dimitriadis, P., Spanoudi, F., Raptis, S. A., & Dimitriadis, G. (2015). Vinegar Consumption Increases Insulin-Stimulated Glucose Uptake by the Forearm Muscle in Humans with Type 2 Diabetes. Journal of Diabetes Research, 2015. https://doi.org/10.1155/2015/175204
Murray, R. K., Bender, D. A., Botham, K. M., Kennelly, P. J., Rodwell, V. W., & Weil, P. A. (2017). Biokimia Harper (R. Soeharsono, F. Sandra, & H. O. Ong (eds.); 29th ed.). McGraw-Hill Higher Education.
Ogawa, N., Satsu, H., Watanabe, H., Fukaya, M., Tsukamoto, Y., Miyamoto, Y., & Shimizu, M. (2000). Acetic Acid Suppresses the Increase in Disaccharidase Activity that Occurs During Culture of Caco-2 Cells. Journal of Nutrition, 130(3), 507–513. https://doi.org/10.1093/jn/130.3.507
Pangastuti, A., Amin, M., & Indriwati, E. S. (2016). Mengungkap Potensi Senyawa Alami Melalui Teknik Reverse Docking. Prosiding Seminar Nasional II 2016, Kerjasama Prodi Pendidikan Biologi FKIP Dengan Pusat Studi Lingkungan Dan Kependudukan (PSLK) Universitas Muhammadiya Malang, 1, 1019–1028.
Park, K., & Cho, A. E. (2017). Using Reverse Docking to Identify Potential Targets for Ginsenosides. Journal of Ginseng Research, 41(4), 534–539. https://doi.org/10.1016/j.jgr.2016.10.005
Putri, H., Yeni, F., & Handayani, T. (2013). Hubungan Peran Keluarga Dengan Pengendalian Kadar Gula Darah Pada Pasien Diabetes Melitus di Wilayah Kerja Puskesmas Pauh Padang. NERS Jurnal Keperawatan, 9(2), 136. https://doi.org/10.25077/njk.9.2.136-142.2013
Rudi, A., & Kwureh, H. N. (2017). Faktor Risiko yang Mempengaruhi Kadar Gula Darah Puasa Pada Pengguna Layanan Laboratorium. Jurnal Ilmiah Ilmu Kesehatan: Wawasan Kesehatan, 3(2). https://doi.org/10.31227/osf.io/d3kes
Ruiz-Moreno, A. J., Domling, A., & Velasco-Velazquez, M. A. (2020). Cancer Cell Signaling. In M. Robles-Flores (Ed.), Cancer Cell Signaling (Third). Humana Press. https://doi.org/10.1385/1592593569
Sugiyono. (2016). Metode Penelitian Kuantitatif, Kualitatif, dan R&D (23rd ed.). ALFABETA.
Susanti, R., & Febriana, F. (2017). Teknologi Enzim. CV ANDI OFFSET.
Toonen, R. J., Nakayama, T., Ogawa, T., Rossiter, A., & Delbeek, J. C. (2012). Growth of cultured giant clams (Tridacna spp.) in low pH, high-nutrient seawater: Species-specific effects of substrate and supplemental feeding under acidification. Journal of the Marine Biological Association of the United Kingdom, 92(4), 731–740. https://doi.org/10.1017/S0025315411000762
Wahyuni, S. (2017). Biokimia Enzim dan Karbohidrat. Unimal Press.
Zheng, R., Chen, T. sheng, & Lu, T. (2011). A Comparative Reverse Docking Strategy to Identify Potential Antineoplastic Targets of Tea Functional Components and Binding Mode. International Journal of Molecular Sciences, 12(8), 5200–5212. https://doi.org/10.3390/ijms12085200
Zubaidah, E., & Nuril F, I. (2015). Efek Cuka Apel dan Cuka Salak terhadap Penurunan Glukosa Darah dan Histopatologi Pankreas Tikus Wistar. Kedokteran Brawijaya, 28(4), 297–301.
Authors
Dwisandi, R. F., Herawati, D., & Nuryadin, E. (2021). Potential of Bioactive Compounds of Arenga Vinegar as Traditional Medicine Through Reverse Docking Techniques. BIOEDUSCIENCE, 5(2), 142–147. https://doi.org/10.22236/j.bes/526802
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