The activity of Jackfruit Leaf Extract (Artocarpus heterophyllus L.) Against Staphylococcus epidermidis
Abstract
Background: Acne is an infectious disease that is still a severe problem. The therapy used for acne is the bacterial antibiotic Clindamycin. Still, there is a lot of resistance to these antibiotics, one of which is Staphylococcus epidermidis, so it is necessary to find alternative antibacterial drugs to treat acne. Non-pharmacological therapy often used is jackfruit leaf extract (Artocarpus heterophyllus L.) which contains secondary metabolites such as flavonoids, saponins, and tannins, which are thought to be effective as antibacterial agents. Methods: The type of research used is True Experimental with the Posttest-Only Control Group research design. The research method used healthy diffusion and liquid dilution, and then the data were analyzed using ANOVA. Results: It was found that jackfruit leaf extract (Artocarpus heterophyllus L.) had antibacterial activity against Staphylococcus epidermidis with a diameter of inhibition zone at a concentration of 50 ppm of 11.7 mm, a concentration of 75 ppm of 12.1 mm, a concentration of 100 ppm of 12.3 mm and had a minimum inhibitory ability at a concentration of 50 ppm with a p-value of 0.007 in the Kruskall-Wallis Test and the Mann Whitney Test showed a p-value of 0.025. Still, the extract did not have the minimum killing ability. Conclusions: Jackfruit leaf extract can only inhibit the growth of Staphylococcus epidermidis bacteria but cannot kill the growth of these bacteria.
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References
CLSI. 2020. 40 Clsi CLSI M100-ED29: 2021 Performance Standards for Antimicrobial Susceptibility Testing, 30th Edition.
Ekawati, Evy Ratnasari, Siti Nur Husnul Y., and Dheasy Herawati. 2018. “Identifikasi Kuman Pada Pus Dari Luka Infeksi Kulit.” Jurnal SainHealth 2(1): 31.
Hasanah, Nur, and Dede Rival Novian. 2020. “Daya Hambat Ekstrak Daun Belimbing Wuluh ( Averrhoa Bilimbi L ) Terhadap Bakteri Penyebab Jerawat ( Propionibacterium Acnes ).” Journal Ilmiah Farmasi 9(1): 46–53.
Hasnawati, Randa Wulaisfan &. 2017. “Uji Daya Hambat Ekstrak Daun Sukun (Artocarpus Altilis) Terhadap Pertumbuhan Bakteri Staphylococcus Epidermidis.” Warta Farmasi 6(2): 90–99.
Indriastuti, Yulistia Budianti SoemarieAnita AprilianaMeita. 2018. “Uji Aktivitas Antibakteri Ekstrak Etanol Daun Glodokan Tiang (Polyalthia Longifolia S.) Terhadap Bakteri Propionibacterium Acnes.” JFL : Jurnal Farmasi Lampung 7(1).
Madani, Fiytary Noor, Putri Vidiasari Darsono, and Melviani Melviani. 2021. “Antibacterial Activity Of Kumis Kucing Leaf Extract (Orthosiphon Stamineus) Against Propionibacterium Acnes Bacteria.” Journal of Applied Pharmaceutical Science 1(1): 1–4.
Madelina, Winona, and Sulistiyaningsih. 2018. “Review: Resistensi Antibiotik Pada Terapi Pengobatan Jerawat.” Jurnal Farmaka 16(2): 105–17.
Mahdiyah, Dede et al. 2020. “Screening of Indonesian Peat Soil Bacteria Producing Antimicrobial Compounds.” Saudi Journal of Biological Sciences 27(10): 2604–11. https://doi.org/10.1016/j.sjbs.2020.05.033.
Noval, Noval, Iwan Yuwindry, and Dahlia Syahrina. 2019. “Phytochemical Screening and Antimicrobial Activity of Bundung Plants Extract by Dilution Method.” Jurnal Surya Medika 5(1): 143–54.
Radityastuti, Radityastuti, and Primasthi Anggraeni. 2017. “Karakteristik Penyakit Kulit Akibat Infeksi Di Poliklinik Kulit Dan Kelamin RSUP Dr. Kariadi Semarang Periode Januari 2008 – Desember 2010.” Media Medika Muda 2(2): 137–42.
T.M, Putri Vidiasari Darsono & M. Fajriannor. 2020. “Aktivitas Antibakteri Ekstrak Dadangkak (Hydrolea Spinosa) Terhadap Bakteri Bacillus Subtilis, Staphylococcus Aureus Dan Escherichia Coli.” Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 5(1): 117–27.
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