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Abstract
Background: Indonesia sudah mengadopsi program Profilaksis Pra Pajanan sejak tahun 2021 dan sudah dilaksanakan di 10 Propinsi dan 22 Kabupaten. Profilaksis Pra Pajanan (PrEP) merupkan metode pencegahan biomedis HIV yang aman dan sangat efektif ketika penggunanya patuh sepenuhnya. Profilaksis pra pajanan terbukti mengurangi risiko infeksi HIV sebesar 51%. Metode: Program Pengabdian kepada Masyarakat (PkM) yang digunakan adalah Pretest, penyuluhan, diskusi kelompok, dan sesi tanya jawab serta Posttest. Karaketristik peserta berdasarkan usia memiliki rata-rata usia peserta 34.44 tahun dengan usia paling muda 18 tahun dan usia peserta paling tua 54 tahun, dan mayoristas LSL sebanyak 89.5%. Hasil: Uji T Dependen menunjukkan nilai p 0.0001 < 0.05. Hal ini menunjukkan ada kenaikan skor secara siginfikan dari peserta. Efek penyuluhan berpengaruh dalam peningkatan pengetahuan peserta. Kesimpulan: Hal ini menunjukkan bahwa kegiatan penyuluhan yang dilakukan berhasil meningkatkan pengetahuan peserta tentang PreP. Penggunaan PreP sangat ditekankan bagi mereka yang berisiko tinggi dan negatif HIV seperti Lelalki seksusal lelaki, pekerjan seks perempuan dan transgender guna mencegah infeksi HIV baru.
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© 2025 Oleh authors. Lisensi Jurnal SOLMA, LPPM-Uhamka, Jakarta. Artikel ini bersifat open access yang didistribusikan di bawah syarat dan ketentuan Creative Commons Attribution (CC BY) license. (http://creativecommons.org/licenses/by/4.0/).
References
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- Dinas Kesehatan, P. (2023). Data Populasi Kunci di Kota Prabumulih.
- Faussat, C., Bonnin, A., Hilt, D., Rivière-Da Silva, F., Baissin, C., Michels, D., Gras, G., Leclerc, C., Aumond, C., & Grammatico-Guillon, L. (2024). Advantages and limits of remote consultations for HIV pre-exposure prophylaxis health pathway: ePrEP qualitative study. Journal of Epidemiology and Population Health, 72(2), 202201. https://doi.org/10.1016/j.jeph.2024.202201
- Fonner, V. A., Dalglish, S. L., Kennedy, C. E., Baggaley, R., O’reilly, K. R., Koechlin, F. M., Rodolph, M., Hodges-Mameletzis, I., & Grant, R. M. (2016). Effectiveness and safety of oral HIV preexposure prophylaxis for all populations. Aids, 30(12), 1973–1983. https://doi.org/10.1097/qad.0000000000001145
- Geneva, U. (2020). UNAIDS Report on the Global AIDS Epidemic Shows that 2020 Targets will not be MET Because of Deeply Unequal Success; COVID-19 Risks Blowing HIV Progress Way Off Course. UNAIDS.
- Grant, R. M., Mannheimer, S., Hughes, J. P., Hirsch-Moverman, Y., Loquere, A., Chitwarakorn, A., Curlin, M. E., Li, M., Amico, K. R., Hendrix, C. W., Anderson, P. L., Dye, B. J., Marzinke, M. A., Piwowar-Manning, E., McKinstry, L., Elharrar, V., Stirratt, M., Rooney, J. F., Eshleman, S. H., … Holtz, T. H. (2018). Daily and Nondaily Oral Preexposure Prophylaxis in Men and Transgender Women Who Have Sex With Men: The Human Immunodeficiency Virus Prevention Trials Network 067/ADAPT Study. Clinical Infectious Diseases, 66(11), 1712–1721. https://doi.org/10.1093/cid/cix1086
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- Hojilla, J. C., Marcus, J. L., Silverberg, M. J., Hare, C. B., Herbers, R., Hurley, L., Satre, D. D., & Volk, J. E. (2020). Early adopters of event-driven human immunodeficiency virus pre-exposure prophylaxis in a large healthcare system in San Francisco. Clinical Infectious Diseases, 71(10), 2710–2712. https://doi.org/10.1093/cid/ciaa474
- https://www.kemkes.go.id. (2020). Pusat Data dan Informasi Kementerian Kesehatan. Diakses 2 Februari 2023.
- Kementrian Kesehatan RI. (2023). Guidelines for oral pre-expose prophylaxis (PREP) program for people at high-risk of HIV infection in Indonesia. 2023; 1–64.
- Liegeon, G., Delaugerre, C., & Molina, J.-M. (2024). HIV pre-exposure prophylaxis. Infectious Disease Clinics, 38(3), 453–474. https://doi.org/10.1016/j.idc.2024.04.003
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- Rainer, C., Schnall, R., Tanner, M. R., Galindo, C. A., Hoover, K. W., Naar, S., Brin, M., Martinez, A., Jia, H., Mendoza, M., & Hightow-Weidman, L. (2025). Developing and Implementing Provider-Training and Evidence-Based Tools to Support Pre-exposure Prophylaxis (PrEP) Decision-Making and Increase PrEP Adherence Among Young Men Who Have Sex With Men: Protocol for the PrEP Choice Longitudinal Cohort Study. JMIR Research Protocols, 14. https://doi.org/10.2196/64186
- Sewell, W. C., Solleveld, P., Seidman, D., Dehlendorf, C., Marcus, J. L., & Krakower, D. S. (2021). Patient-led decision-making for HIV preexposure prophylaxis. Current HIV/AIDS Reports, 18, 48–56. https://doi.org/10.1007/s11904-020-00535-w
- Sousa, A. F. L., Lima, S. V. M. A., Ribeiro, C. J. N., de Sousa, A. R., Barreto, N. M. P. V., Camargo, E. L. S., Araújo, A. A. C., Dos Santos, A. D., Bezerra-Santos, M., Fortunato, M. D. R., Possani, M. A., Santos, A. J. D., Lima, J. L. T., Gir, E., Fronteira, I., & Mendes, I. A. C. (2023). Adherence to Pre-Exposure Prophylaxis (PrEP) among Men Who Have Sex with Men (MSM) in Portuguese-Speaking Countries. International journal of environmental research and public health, 20(6), 4881. https://doi.org/10.3390/ijerph20064881
- UNAIDS. (2022). Global HIV & AIDS statistics — Fact sheet. https://Www.Unaids.Org.
- Vaccher, S. J., Gianacas, C., Templeton, D. J., Poynten, I. M., Haire, B. G., Ooi, C., Foster, R., McNulty, A., Grulich, A. E., Zablotska, I. B., & PRELUDE Study Team (2017). Baseline Preferences for Daily, Event-Driven, or Periodic HIV Pre-Exposure Prophylaxis among Gay and Bisexual Men in the PRELUDE Demonstration Project. Frontiers in public health, 5, 341. https://doi.org/10.3389/fpubh.2017.00341
- Van Dijk, M., de Wit, J.B.F., Guadamuz, T.E. et al. Slow Uptake of prep: Behavioral Predictors and the Influence of Price on prep Uptake Among MSM with a High Interest in prep. AIDS Behav 25, 2382–2390 (2021). Https://doi.org/10.1007/s10461-021-03200-4
- WHO. (2015). Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV. World Health Organization. https://www.who.int/publications/i/item/9789241509565
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- Xu, J., Huang, X., Liu, X., Wang, L., Chen, Y., Wang, H., Zhang, F., Wu, H., Li, T., & Han, M. (2020). Expert consensus on pre-exposure prophylaxis for HIV in China. Chin. J. AIDS STD, 26, 1265–1271.
- (YIM), Y. I. M. (2023). Estimasi populasi kunci pekerja seks komersial di kota palembang Tahun 2023.
References
Crossman, J., & Richardson, D. (2025). Barriers to HIV pre-exposure prophylaxis uptake for men who have sex with both men and women: A global scoping review. International Journal of STD & AIDS, 36(6), 450–468. https://doi.org/10.1177/09564624251321564
Dinas Kesehatan, P. (2023). Data Populasi Kunci di Kota Prabumulih.
Faussat, C., Bonnin, A., Hilt, D., Rivière-Da Silva, F., Baissin, C., Michels, D., Gras, G., Leclerc, C., Aumond, C., & Grammatico-Guillon, L. (2024). Advantages and limits of remote consultations for HIV pre-exposure prophylaxis health pathway: ePrEP qualitative study. Journal of Epidemiology and Population Health, 72(2), 202201. https://doi.org/10.1016/j.jeph.2024.202201
Fonner, V. A., Dalglish, S. L., Kennedy, C. E., Baggaley, R., O’reilly, K. R., Koechlin, F. M., Rodolph, M., Hodges-Mameletzis, I., & Grant, R. M. (2016). Effectiveness and safety of oral HIV preexposure prophylaxis for all populations. Aids, 30(12), 1973–1983. https://doi.org/10.1097/qad.0000000000001145
Geneva, U. (2020). UNAIDS Report on the Global AIDS Epidemic Shows that 2020 Targets will not be MET Because of Deeply Unequal Success; COVID-19 Risks Blowing HIV Progress Way Off Course. UNAIDS.
Grant, R. M., Mannheimer, S., Hughes, J. P., Hirsch-Moverman, Y., Loquere, A., Chitwarakorn, A., Curlin, M. E., Li, M., Amico, K. R., Hendrix, C. W., Anderson, P. L., Dye, B. J., Marzinke, M. A., Piwowar-Manning, E., McKinstry, L., Elharrar, V., Stirratt, M., Rooney, J. F., Eshleman, S. H., … Holtz, T. H. (2018). Daily and Nondaily Oral Preexposure Prophylaxis in Men and Transgender Women Who Have Sex With Men: The Human Immunodeficiency Virus Prevention Trials Network 067/ADAPT Study. Clinical Infectious Diseases, 66(11), 1712–1721. https://doi.org/10.1093/cid/cix1086
Guan, Y., Qi, T., Liao, Q., Zhang, R., Chen, J., Liu, L., Shen, Y., Zhu, H., Tang, Q., & Lu, H. (2023). Multi-dimensional mismatch and barriers for promoting PrEP among men who have sex with men in China: a cross sectional survey from the Demand-side. AIDS Research and Therapy, 20(1), 11. https://doi.org/10.1186/s12981-022-00497-6
Hojilla, J. C., Marcus, J. L., Silverberg, M. J., Hare, C. B., Herbers, R., Hurley, L., Satre, D. D., & Volk, J. E. (2020). Early adopters of event-driven human immunodeficiency virus pre-exposure prophylaxis in a large healthcare system in San Francisco. Clinical Infectious Diseases, 71(10), 2710–2712. https://doi.org/10.1093/cid/ciaa474
https://www.kemkes.go.id. (2020). Pusat Data dan Informasi Kementerian Kesehatan. Diakses 2 Februari 2023.
Kementrian Kesehatan RI. (2023). Guidelines for oral pre-expose prophylaxis (PREP) program for people at high-risk of HIV infection in Indonesia. 2023; 1–64.
Liegeon, G., Delaugerre, C., & Molina, J.-M. (2024). HIV pre-exposure prophylaxis. Infectious Disease Clinics, 38(3), 453–474. https://doi.org/10.1016/j.idc.2024.04.003
Liu, Y., Liu, X., Wei, S., Cheng, Z., Xian, Y., Zhao, Y., Ma, J., Chen, J., Chen, Z., Yang, J., Liu, F., Yu, M., Cui, Z., & Li, C. (2024). Identifying patterns of sexual behaviors and PrEP uptake characteristics among MSM who were eligible for PrEP: A national cross-section study. Journal of Virus Eradication, 10(2), 100382. doi: https://doi.org/10.1016/j.jve.2024.100382
Nigat, A. B., Abate, M. W., Demelash, A. T., Bantie, B., Tibebu, N. S., Tiruneh, C. M., Emiru, T. D., Yimam, M. A., Legas, G., & Yimer, Y. S. (2024). Predictors of HIV/AIDS preventive behavior among undergraduate health science university students in Northwest Ethiopia, 2022. Institution-based cross-sectional study. Heliyon, 10(11), e32453. https://doi.org/10.1016/j.heliyon.2024.e32453
Organization, W. H. (2022). Guidelines on long-acting injectable cabotegravir for HIV prevention. World Health Organization. https://www.who.int/publications/i/item/9789240054097
Chou, R., Evans, C., Hoverman, A., Sun, C., Dana, T., Bougatsos, C., Grusing, S., & Korthuis, P. T. (2019). Preexposure Prophylaxis for the Prevention of HIV Infection: Evidence Report and Systematic Review for the US Preventive Services Task Force. JAMA, 321(22), 2214–2230. https://doi.org/10.1001/jama.2019.2591
Rainer, C., Schnall, R., Tanner, M. R., Galindo, C. A., Hoover, K. W., Naar, S., Brin, M., Martinez, A., Jia, H., Mendoza, M., & Hightow-Weidman, L. (2025). Developing and Implementing Provider-Training and Evidence-Based Tools to Support Pre-exposure Prophylaxis (PrEP) Decision-Making and Increase PrEP Adherence Among Young Men Who Have Sex With Men: Protocol for the PrEP Choice Longitudinal Cohort Study. JMIR Research Protocols, 14. https://doi.org/10.2196/64186
Sewell, W. C., Solleveld, P., Seidman, D., Dehlendorf, C., Marcus, J. L., & Krakower, D. S. (2021). Patient-led decision-making for HIV preexposure prophylaxis. Current HIV/AIDS Reports, 18, 48–56. https://doi.org/10.1007/s11904-020-00535-w
Sousa, A. F. L., Lima, S. V. M. A., Ribeiro, C. J. N., de Sousa, A. R., Barreto, N. M. P. V., Camargo, E. L. S., Araújo, A. A. C., Dos Santos, A. D., Bezerra-Santos, M., Fortunato, M. D. R., Possani, M. A., Santos, A. J. D., Lima, J. L. T., Gir, E., Fronteira, I., & Mendes, I. A. C. (2023). Adherence to Pre-Exposure Prophylaxis (PrEP) among Men Who Have Sex with Men (MSM) in Portuguese-Speaking Countries. International journal of environmental research and public health, 20(6), 4881. https://doi.org/10.3390/ijerph20064881
UNAIDS. (2022). Global HIV & AIDS statistics — Fact sheet. https://Www.Unaids.Org.
Vaccher, S. J., Gianacas, C., Templeton, D. J., Poynten, I. M., Haire, B. G., Ooi, C., Foster, R., McNulty, A., Grulich, A. E., Zablotska, I. B., & PRELUDE Study Team (2017). Baseline Preferences for Daily, Event-Driven, or Periodic HIV Pre-Exposure Prophylaxis among Gay and Bisexual Men in the PRELUDE Demonstration Project. Frontiers in public health, 5, 341. https://doi.org/10.3389/fpubh.2017.00341
Van Dijk, M., de Wit, J.B.F., Guadamuz, T.E. et al. Slow Uptake of prep: Behavioral Predictors and the Influence of Price on prep Uptake Among MSM with a High Interest in prep. AIDS Behav 25, 2382–2390 (2021). Https://doi.org/10.1007/s10461-021-03200-4
WHO. (2015). Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV. World Health Organization. https://www.who.int/publications/i/item/9789241509565
Wu, H. J., Wen-Wei Ku, S., Chang, H. H., Li, C. W., Ko, N. Y., & Strong, C. (2021). Imperfect adherence in real life: a prevention-effective perspective on adherence to daily and event-driven HIV pre-exposure prophylaxis among men who have sex with men - a prospective cohort study in Taiwan. Journal of the International AIDS Society, 24(5), e25733. https://doi.org/10.1002/jia2.25733
Xu, J., Huang, X., Liu, X., Wang, L., Chen, Y., Wang, H., Zhang, F., Wu, H., Li, T., & Han, M. (2020). Expert consensus on pre-exposure prophylaxis for HIV in China. Chin. J. AIDS STD, 26, 1265–1271.
(YIM), Y. I. M. (2023). Estimasi populasi kunci pekerja seks komersial di kota palembang Tahun 2023.
