LITERATURE REVIEW : PERAN SUPLEMENTASI VITAMIN D DALAM MODULASI IMUN PADA PENDERITA HIV-1

Sarah Aulya Chabita; Yessi Octaria

doi:10.22236/argipa.v9i2.15229

Authors

Sarah Aulya Chabita Program Studi Gizi, Fakultas Ilmu Kesehatan, Universitas Pembangunan Nasional “Veteran” Jakarta, Indonesia
Yessi Octaria Program Studi Gizi, Fakultas Ilmu Kesehatan, Universitas Pembangunan Nasional “Veteran” Jakarta, Indonesia

DOI:

https://doi.org/10.22236/argipa.v9i2.15229

Keywords:

HIV-1, immune modulation, vitamin d supplementation

Abstract

Human Immunodeficiency Virus (HIV) is a retrovirus that attacks immune cells such as CD4+ cells and macrophages, causing a decline in the immune system that can develop into Acquired Immunodeficiency Syndrome (AIDS). The purpose of this study was to review the role and mechanism of vitamin D supplementation in immune modulation in adults with HIV-1. This study used the literature review method and PICOS to evaluate the effect of vitamin D supplementation on immune modulation in adult HIV-1 patients. Data were collected from PubMed, Elsevier, and Google Scholar databases for the period 2014-2024, using the related search terms “Vitamin D supplementation” or “Cholecalciferol” and “Immune Modulation” or “Immune System” or “Immune” and “Adult” and “HIV-1” and “RCT” or “Randomized Controlled Trial”. Vitamin D supplementation has a positive impact and role in immune modulation, including increased CD4+ T cell counts and markers of immune response. Six relevant articles that met the inclusion criteria were identified and analyzed. Although vitamin D supplementation increases blood levels of vitamin D and aids immune modification, its effect on viral load has not been confirmed. The common dose of vitamin D used in studies ranged from 7.000 IU for 12 months or 12 weeks. Vitamin D supplementation shows potential as an adjunctive therapy for HIV-1, but further trials with larger populations are needed to confirm the optimal dose and long-term effects.

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