VITAMIN D PADA KEHAMILAN

Abstract

Vitamin D defciency or insuffciency, including global public health problem. Vitamin
D status in pregnancy plays an important role on maternal and fetal health. Beside the classical
role in bone and mineral metabolism, vitamin D and vitamin D receptor gene (VDR) is the key
stimulating the proliferation and differentiation approximately 200-300 genes, which many of
them regulate fetal development, it makes vitamin D important in pregnancy. The aim of this
review is to explain how vitamin D-related implications on maternal and fetal health. Many
of the research concentration 25(OH)D serum levels is associated with pregnancy outcomes
74 Volume 1, Nomor 2, Julii─Desember 2016
such as preeclampsia, Gestational Diabetes Mellitus, Caesar birth delivery, bone health,
preterm birth, intra uterine growth retardation, small for gestational age, and low birth weight.
Pregnant mothers need higher vitamin D than usual. Therefore, a recommendation of vitamin
D supplementation is needed for pregnant mothers who are defcient, safe and effective dose is
4000 IU/day. The main source of vitamin D is most effective sun exposure UVB (90%) and
food (10%). The main determining factors affecting vitamin D status were the lifestyle, sun
exposure behavior (use of sunblock, clothes, latitude, sunscreens) and low food intake of vitamin
D. Therefore, women who undergo frst antenatal care recommended to be given information
regarding the importance of the role of vitamin D during pregnancy for maternal and fetal
health.