FORMULATIONS GEL OF TUNA BONE COLLAGEN (Thunnus albacares) WITH HPMC AS A GELLING AGENT

ari widayanti, Desti Ayu Fauziah, Naniek Setiadi Radjab

Abstract

Tuna's collagen may be applied to burns at 2%. To provide convenience in use it was made in drug form gel. HPMC is used as a gelling agent because it can form a gel that is clear and netral and has a viscosity that is stable in a long periode. This study aims to determine the effect of  increase in the concentration of HPMC as a gelling agent in the gel formula. at a concentration of 3%, 4%, 5%, 6%, 7%. The resulting gel is then evaluated by the organoleptic test, homogeneity test, pH test, viscosity test, centrifugation test, and freeze thaw test. Result of statistical analysis ANOVA one way to test the viscosity of the significant difference in each formula. Based on the result of this study concluded that the increased concentration of HPMC as a gelling agent can increase the viscosity of bone collagen gel tuna.

Full text article

Generated from XML file

References

Agoes G. 2012. Sediaan Farmasi Liquida-semisolida. ITB. Bandung. Hlm. 327-328
Departemen Kesehatan RI. 1995. Farmakope Indonesia Edisi IV. Depertemen Kesehatan Republik Indonesia. Jakarta. Hlm. 7-8, 157, 551, 712,713, 1039
Herdianta.2013.Efektivitas Senyawa Kolagen Dari Tulang Ikan Tuna (Thunnus albacares) Terhadap Penyembuhan Luka Bakar Pada Tikus Putih (Rattus norwegicus). Skripsi.Fakultas Farmasi dan Sains UHAMKA, Jakarta. Hlm. 3, 5, 6, 18, 31.
Lachman L, liberman, AH, Kanig, LJ. 1994.Teori dan Praktek Farmasi Industri. Edisi ketiga.Terjemahan: Siti Suyatmi. Universitas Indonesia. Hlm. 777,1081, 1119
Lee CH, Anuj S, Yungyung L.2001. Review: Biomedical Application of Collagen. Int. J. of Pharm. 221. Hlm. 1-22
Sari M. 2011. Identifikasi Protein Menggunakan Fourier Transform Infrared (FTIR). Skripsi. Universitas Indonesia, Depok. Hlm 18
Wade A., Walter, P.J. 1994. Handbook of pharmaceutical Excipients 2nd.American Pharmaceutical Association and pharmaceutical Washington.The Pharmaceutical Press. London. Hlm. 229.

Authors

ari widayanti
ariwidayanti123@gmail.com (Primary Contact)
Desti Ayu Fauziah
Naniek Setiadi Radjab
widayanti, ari, Fauziah, D. A. and Radjab, N. S. (2016) “FORMULATIONS GEL OF TUNA BONE COLLAGEN (Thunnus albacares) WITH HPMC AS A GELLING AGENT”, Farmasains : Jurnal Ilmiah Ilmu Kefarmasian, 3(1), pp. 1–6. Available at: https://journal.uhamka.ac.id/index.php/farmasains/article/view/138 (Accessed: 24 November 2024).
Copyright and license info is not available

Article Details