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Abstract
This descriptive study describes the proportion of Epidermal Growth Factor Receptor (EGFR) mutations in lung cancer Adenocarcinoma patients at Rumah Sakit Paru (RS Paru) Dr. H. A Rotinsulu Bandung in the range of 2018 to 2020.
EGFR mutations were examined using RGQ thera screen technology Real"‘Time Polymerase Chain Reaction from FFPE or cytology smear.
There are 44 data point mutations after examining the EGFR mutation. 59% cases were 40"‘60 years old group dan 52 % were female.
It was found that in this group 86% patient with single mutation and 16% had doube mutations. EGFR mutations occurred in Exon 21 L858R in 13 cases (30 %), Exon 21 L861Q in 1 case (2%), Exon 19del in 24 cases (55%), double mutation Exon 19 and Exon 20 T790M type in 2 cases (4%), double mutation Exon 19del and Exon 21 in 4 cases (9%).
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References
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References
Hudoyo A, Wibawanto A, Lutfi A, Rima A, et al. Pedoman Nasional Pelayan Kedokteran Kanker Paru : Kementerian Kesehatan Republik Indonesia.2017
Sung H, Ferlay J, Siegel R.L , Laversanne M, Soerjomataram I, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries : Cancer J Clin. 2021;71:209–249.
TravisWD, Brambilla E, Burke AP, Marx A, Nicholson AG. WHO Classification of tumour. Pathology and genetics Tumours of The Lung, Pleura, Thymus and Heart.2015. P : 1"‘44.
Ettinger DS, Wood DE, Anggarwal C, Aisner DL, et.al. NCCN Guidelines Version 1.2020 Non Small Cell Lung Cancer: National Comprehensive Cancer Network.2020.
Shi Y, Au JS, Thongprasert S, Srinivasan S, Tsai CM, Khoa MT, Heeroma K, Itoh Y, Cornelio G, Yang PC. A prospective, molecular epidemiology study of EGFR mutations in Asian patients with advanced non"‘small"‘cell lung cancer of adenocarcinoma histology (PIONEER). J T h o r a c O n c o l . 2 0 1 4 F e b ; 9 ( 2 ) : 1 5 4 "‘ 6 2 . d o i :
1097/JTO.0000000000000033. PMID: 24419411; PMCID: PMC4132036.
Wu SG, Chang YL, Yu CJ, Yang PC, Shih JY. Lung adenocarcinoma patients of young age have lower EGFR mutation rate and poorer efficacy of EGFR tyrosine kinase inhibitors. ERJ Open Res. 2017;3(3):00092"‘2016. Published 2017 Jul 12. doi:10.1183/23120541.00092"‘2016
Lv, Li Liu, Zhichao Liu, Yang Zhang, Wenhui Jiang, Lifeng Li, Tingting Lu, Xinyan Lei, Xuefen Liang, Wenhua Lin, Jie. (2020). Distinct EGFR Mutation Pattern in Patients With Non"‘Small Cell Lung Cancer in Xuanwei Region of China: A Systematic Review and Meta"‘Analysis. Frontiers in Oncology. doi: 10. 10.3389/fonc.2020.519073.