Main Article Content


Background. Metaplastic breast carcinoma is a very rare breast cancer, only about 0.2"‘1% of all invasive breast carcinomas. The prognosis of these cancer is poor and aggressive, reported to have lower response rates to conventional adjuvant chemotherapy and a worse clinical outcome after chemotherapy than other forms triple"‘negative breast carcinomas. Histopathologically, metaplastic breast carcinoma has distinct patterns with different outcomes. Among the types of metaplastic carcinoma, squamous cell, high grade spindle cell and high grade adenosquamous carcinoma are associated with the worst prognosis. We report one case of metaplastic breast carcinoma with squamous differentiation in young patient.

Methods. We examined the breast tumor tissue of a female patient, evaluated the macroscopic and microscopic features and asked the patient about the clinical course of the disease. Inform consent was obtained from the patient for publication of this case report and accompanying images.

Results. We reported a young female patient with final diagnosis of pathology Mixed Infiltrating Duct Carcinoma of No Special Type Grade 3 and Metaplastic Breast Carcinoma with Squamous Differentiation (30%) that has invaded fat tissue with Ductal Carcinoma Insitu of High Nuclear Grade 3 with basis of the operation is still positive for the tumor mass. Patients lost follow"‘up and did not continue therapy.

Conclusion. Morphology of metaplastic breast carcinoma are important factors influencing patient outcome. Early diagnosis and wide local excision of the squamous"‘type metaplastic breast carcinoma mass can make a better prognosis.


Metaplastic Breast Carcinoma Squamous cell carcinoma infiltrating duct carcinoma case report Histopathology Squamous differentiation

Article Details

How to Cite
Agustina, R. (2022). A Rare Case of Metaplastic Breast Carcinoma with Squamous Differentiation in Young Female: A Case Report. Sanus Medical Journal, 3(1), 5–8.


  1. Reis-Filho J, Gobbi H. Invasive Breast Carcinoma. In: WHO, editor. Breast Tumours. 5th ed. France: IARC Press; 2019. p. 134–8.
  2. Huvos AG, Lucas JC Jr FFJr. Metaplastic breast carcinoma. Rare form of mammary cancer. M N Y State J Med. 1973;73:1078–1082.
  3. Konkankit V V, Reusser GE, Ding PD. A Case Report on a Rare Finding : Metaplastic Squamous Cell Carcinoma of the Breast. the American Journal of Hematology/Oncology®. 2016;(September):4–7.
  4. Pandey A, Joshi K, Moussouris H, Joseph G. Case Reports on Metaplastic Squamous Cell Carcinoma of the Breast and Treatment Dilemma. Case Reports in Oncological Medicine. 2019;2019:1–6.
  5. Ramos V, Fraga J, Simíµes T, Figueiredo Dias M. Intracystic Primary Squamous Cell Carcinoma of the Breast: A Challenging Diagnosis. Case Reports in Obstetrics and Gynecology. 2016;2016(Figure 1):1–4.
  6. Buchanan PJ, Chopra VK, Walker KL, Rudolph R, Greco RJ. Primary Squamous Cell Carcinoma Arising from a Breast Implant Capsule: A Case Report and Review of the Literature. Aesthetic Surgery Journal. 2018;38(7):NP97–102.
  7. Nowara E, Drosik A, Samborska-Plewicka M, Nowara EM, Stanek-Widera A. Metaplastic breast carcinomas - Analysis of prognostic factors in a case series. Wspolczesna Onkologia. 2014;18(2):116–9.
  8. McMullen ER, Zoumberos NA, Kleer CG. Metaplastic breast carcinoma update on histopathology and molecular alterations. Archives of Pathology and Laboratory Medicine. 2019;143(12):1492–6.
  9. Pezzi CM, Patel-Parekh L, Cole K, Franko J, Klimberg VS, Bland K. Characteristics and treatment of metaplastic breast cancer: Analysis of 892 cases from the national cancer data base. Annals of Surgical Oncology. 2007;14(1):166–73.
  10. Jung SY, Kim HY, Nam BH, Min SY, Lee SJ, Park C, et al. Worse prognosis of metaplastic breast cancer patients than other patients with triple-negative breast cancer. Breast Cancer Research and Treatment. 2010;120(3):627–37.
  11. Aydiner A, Sen F, Tambas M, Ciftci R, Eralp Y, Saip P, et al. Metaplastic breast carcinoma versus triple-negative breast cancer: Survival and response to treatment. Medicine (United States). 2015;94(52):1–7.