Review Jurnal: Pemanfaatan Etosom Sebagai Bentuk Sediaan Patch
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Issue
Vol. 8 No. 1 (2021)
Submitted
August 11, 2020
Published
April 29, 2021
Abstract
Etosom merupakan suatu sistem pembawa berupa vesikel yang lunak dan elastis dengan komponen utama yaitu fosfopilid, etanol dengan konsentrasi yang cukup tinggi (20-45%), dan air. Etosom memiliki kemampuan dalam meningkatkan penetrasi obat lebih jauh ke dalam kulit dikarenakan adanya kandungan fosfolipid dan etanol. Etosom juga dapat menghantarkan obat hingga mencapai sirkulasi sistemik sehingga sangat cocok digunakan sebagai sistem pembawa yang diformulasikan kedalam bentuk sediaan, salah satunya sediaan patch transdermal. Penggunaan etosom dalam sediaan patch transdermal dapat meningkatkan kemampuan penetrasi, permeabilitas dan bioavailabilitas dari suatu obat. Review ini memberikan informasi mengenai pemanfaatan etosom sebagai bentuk sediaan patch.
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References
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Alagumuthu, M., Dahiya, D., dan Nigam, P.S., 2019. Phospholipid: the Dynamic Structure Between Living and non-Living World; a Much Obligatory Supramolecule for Present and Future. AIMS Molecular Science, 6(1), 1–19.
Arifin, A., Sartini, dan Marianti, 2019. Evaluasi Karakteristik Fisik dan Uji Permeasi pada Formula Patch Aspirin Menggunakan Kombinasi Etilselulosa dengan Polivinilpirolidon. Jurnal Sains dan Kesehatan, 2(1), 40-49.
Bodade, S.S., Shaikh, K.S., Kamble, M.S., dan Chaudhari, P.D., 2013. A Study on Ethosomes as Mode for Transdermal Delivery of an Antidiabetic Drug. Drug Delivery, 20(1), 40–46.
Bragagni, M., Mennini, N., Maestrelli, F., Cirri, M., dan Mura, P., 2012. Comparative Study of Liposomes, Transfersomes and Ethosomes as Carriers for Improving Topical Delivery of Celecoxib. Drug Delivery, 19(7), 354–361.
Dave, V., Kumar, D., Lewis, S., dan Paliwal, S., 2010. Ethosome for Enhanced Transdermal Drug Delivery of Aceclofenac. International Journal of Drug Delivery, 2(1), 81–92.
Ermawati, D.E., dan Prilantari, H.U., 2019. Pengaruh Kombinasi Polimer Hidroksipropilmetilselulosa dan Natrium Karboksimetilselulosa terhadap Sifat Fisik Sediaan Matrix-based Patch Ibuprofen. Journal of Pharmaceutical Science and Clinical Research, 2(1), 109–119.
Fatmawaty, A., Nisa, M., Irmayani, dan Sunarti, 2017. Formulasi Patch Ekstrak Etanol Daun Murbei (Morus Alba L.) dengan Variasi Konsentrasi Polimer Polivinil Pirolidon dan Etil Selulosa. Journal of Pharmaceutical and Medicinal Sciences, 2(1), 17–20.
Fiume, M.M., Bergfeld, W.F., Belsito, D.V, Hill, R.A., Klaassen, C.D., Liebler, D., Jr, J.G.M., Shank, R.C., Slaga, T.J., Snyder, P.W., dan Andersen, F.A., 2012. Safety Assessment of Propylene Glycol, Tripropylene Glycol, and PPGs as Used in Cosmetics. International Journal of Toxicology, 31(2), 245S–260S.
Gaikwad, Kaveri A.B.S., dan Somwanshi, A.P., 2017. Ethanolic Vesicles: A Novel Approach to Enhance Transdermal Drug Delivery. Indo American Journal of Pharmaceutical Research, 7(1), 7440–7450.
Hendradi, N., Isnaeni, N., Fridayanti, A., dan Pujianti, E., 2011. Optimasi Sediaan Transdermal Patch Natrium Diklofenak Tipe Matriks. Jumal Farmasi Indonesia, 5(3), 112–119.
Hermanto, F.J., Lestari, F., Hermawati, C., dan Nurviana, V., 2019. Evaluasi Sediaan Patch Daun Handeulem (Graptophyllum griff L.) sebagai Penurun Panas. Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-Ilmu Keperawatan, Analis Kesehatan dan Farmasi, 19(2), 208–217.
Jaiswal, P.K., Kesharwani, S., Kesharwani, R., dan Patel, D.K., 2016. Ethosome: A New Technology Used as Topical and Transdermal Delivery System. Journal of Drug Delivery and Therapeutics, 6(3), 6–17.
Kumar, E., dan Patra, N., 2020. Development Characterization Optimization of Ethosome Containing Duloxetine for Transdermal Delivery. International Journal of Pharmaceutical Sciences and Research, 11(2), 652–659.
Limsuwan, T., Boonme, P., Khongkow, P., dan Amnuaikit, T., 2017. Ethosomes of Phenylethyl Resorcinol as Vesicular Delivery System for Skin Lightening Applications. BioMed Research International, 2(3), 1–12.
Liu, X., Liu, H., Liu, J., He, Z., Ding, C., Huang, G., Zhou, W., dan Zhou, L., 2011. Preparation of a Ligustrazine Ethosome Patch and its Evaluation in Vitro and in Vivo. International Journal of Nanomedicine, 6(1), 241–247.
Ma, H., Guo, D., Fan, Y., Wang, J., Cheng, J., dan Zhang, X., 2018. Paenol-Loaded Ethosomes as Transdermal Delivery Carriers: Design, Preparation and Evaluation. Molecule, 23(7), 1–15.
Mohanty, D., Mounika, A., Bakshi, V., Haque, A.M., dan Sahoo, K.C., 2018. Ethosomes: A Novel Approach for Transdermal Drug Delivery. International Journal of ChemTech Research, 11(8), 219–226.
Nagadevi, B., Kumar, K.S., Venkanna, P., dan Prabhakar, D., 2014. Formulation and Characterisation of Tizanidine Hydrochloride Loaded Ethosomes Patch. International Journal of Pharmacy and Pharmaceutical Sciences, 6(4), 199–205.
Nandure, H.P., Prashant, P., Prabhanjan, G., dan Vidya, L., 2013. Ethosome: A Novel Drug Carrier International Journal of Pharmaceutical Sciences and Allied Research (Impact Factor 3.181). International Journal of Pharmaceutical Research & Allied Sciences, 2(3), 18–30.
Niu, X.Q., Zhang, D.P., Bian, Q., Feng, X.F., Li, H., Rao, Y.F., Shen, Y.M., Geng, F.N., Yuan, A.R., Ying, X.Y., dan Gao, J.Q., 2019. Mechanism Investigation of Ethosomes Transdermal Permeation. International Journal of Pharmaceutics, 2(1), 1–13.
Nurmesa, A., Nurhabibah, dan Najihudin, A., 2019. Formulasi dan Evaluasi Stabilitas Fisik Patch Transdermal Alkaloid Nikotin Daun Tembakau (Nicotiana tobacum Linn) dengan Variasi Polimer dan Asam Oleat. Jurnal Penelitian Farmasi Herbal, 2(1), 1–8.
Pandey, V., Golhani, D., dan Shukla, R., 2015. Ethosomes: Versatile Vesicular Carriers for Efficient Transdermal Delivery of Therapeutic Agents. Drug Delivery, 22(8), 988–1002.
Patrekar, P.V, Inamdar, S.J., Mali, S.S., Mujib, M.T., Ahir, A.A., dan Hosmani A.H., 2015. Ethosomes As Novel Drug Delivery System: A Review. The Pharma Innovation Journal, 4(49), 10–21.
Prabhakara, P., Koland, M., Vijaynarayana, K., Harish N.M., Shankar G., Mohd G.A., Narayana C.R., dan Satyanarayana D., 2010. Preparation and Evaluation of Transdermal Patches of Papaverine Hydrochloride. International Journal of Research in Pharmaceutical Sciences, 1(3), 259–266.
Prasanthi, D., dan Lakshmi, P.K., 2012. Development of Ethosomes with Taguchi Robust Design-Based Studies for Transdermal Delivery of Alfuzosin Hydrochloride. International Current Pharmaceutical Journal, 1(11), 370–375.
Purnamasari, N., Alatas, F., dan Gozali, D., 2019. Formulasi dan Evaluasi Transdermal Patch Kalium Diklofenak. Jurnal Ilmiah Farmasi, 7(1), 43–48.
Rahim, F., Deviarny, C., Yenti, R., dan Ramadani, P., 2016. Formulasi Sediaan Patch Transdermal dari Rimpang Rumput Teki (Cyperus Rotundus L.) untuk Pengobatan Nyeri Sendi pada Tikus Putih Jantan. Scientia: Jurnal Farmasi Dan Kesehatan, 6(1), 1–6.
Rakesh, R., dan Anoop, K.R., 2012. Ethosomes for Transdermal and Topical Drug Delivery. International Journal of Pharmacy and Pharmaceutical Sciences, 4(3), 17–24.
Ramadhani, U.K.S., Djajadisastra, J., dan Iskandarsyah, I., 2017. Pengaruh Polimer dan Peningkat Penetrasi Terhadap Karakter Penetrasi Matriks Sediaan Patch Transdermal Karvedilol. Jurnal Ilmu Kefarmasian Indonesia, 15(2), 120–127.
Ramadon, D., dan Mun'im, A., 2016. Pemanfaatan Nanoteknologi dalam Sistem Penghantaran Obat Baru untuk Produk Bahan Alam. Jurnal Ilmu Kefarmasian Indonesia, 14(2), 118–127.
Salmannejad, F., Ghari, T., dan Toliyat, T., 2015. Formulation and Evaluation of Ethosomes for Transdermal Delivery of Clonazepam. International Journal of Biosciences, 6(5), 308–316.
Shen, S., Liu, S.Z., Zhang, Y.S., Du, M.B., Liang, A.H., Song, L.H., dan Ye, Z.G., 2015. Compound Antimalarial Ethosomal Cataplasm: Preparation, Evaluation, and Mechanism of Penetration Enhancement. International Journal of Nanomedicine, 10(1), 4239–4253.
Shukla, T., Verma, A., Upmanyu, N., Mishra, S. S., dan Shilpi, S., 2016. Development and Characterization of Clopidogrel-loaded Ethosomal Transdermal Patch for Antiplatelet Effect. Asian Journal of Pharmaceutics, 10(4), S680–S686.
Singh, A., dan Bali, A., 2016. Formulation and Characterization of Transdermal Patches for Controlled Delivery of Duloxetine Hydrochloride. Journal of Analytical Science and Technology, 7(1), 1–13.
Sultana, B., Rajak, P., Bhuyan, B., Patra, E., Baruah, A., dan Paul, D., 2018. Therapeutic Potential of Herbal Ethosome in Applied Nanotechnology. Saudi Journal of Medical and Pharmaceutical Sciences, 4(4), 443–454.
Suryani, Musnina, W.O.S., dan Anto, A.S., 2017. Optimasi Formula Matriks Patch Transdermal Nanopartikel Teofilin dengan Menggunakan Metode Simplex Lattice Design (SLD). Majalah Farmasi, Sains, dan Kesehatan, 3(1), 26–32.
Thadanki, M., dan Babu, A.K., 2015. Review on Ethosomes: A Novel Approach of Liposomes. International Journal of Phaarmacy and Life Sciences, 6(1), 4171–4176.
Wahid, A.A., Ravouru, N., dan Lakshman, S.R., 2011. Ethosomes: A Tool for Transdermal Drug Delivery, Current Trends in Biotechnology and Pharmacy, 5(1), 972–981.
Wusnah, Bahri, S., dan Hartono, D., 2016. Proses Pembuatan Bioetanol dari Kulit Pisang Kepok (Musa acuminata B.C) secara Fermentasi. Jurnal Teknologi Kimia Unimal, 5(1), 48–56.
Zahid, S. R., Upmanyu, N., Dangi, S., Ray, S. K., Jain, P., dan Parkhe, G., 2018. Ethosome: A Novel Vesicular Carrier for Transdermal Drug Delivery. Journal of Drug Delivery snd Therapeutics, 8(6), 318–326.
Akib, N.I., Suryani, Halimahtussaddiyah, R., dan Prawesti, N., 2014. Preparasi Fenilbutazon dalam Pembawa Vesikular Etosom dengan Berbagai Variasi Konsentrasi Fosfatidilkolin dan Etanol. Medula, 2(1),112–118.
Alagumuthu, M., Dahiya, D., dan Nigam, P.S., 2019. Phospholipid: the Dynamic Structure Between Living and non-Living World; a Much Obligatory Supramolecule for Present and Future. AIMS Molecular Science, 6(1), 1–19.
Arifin, A., Sartini, dan Marianti, 2019. Evaluasi Karakteristik Fisik dan Uji Permeasi pada Formula Patch Aspirin Menggunakan Kombinasi Etilselulosa dengan Polivinilpirolidon. Jurnal Sains dan Kesehatan, 2(1), 40-49.
Bodade, S.S., Shaikh, K.S., Kamble, M.S., dan Chaudhari, P.D., 2013. A Study on Ethosomes as Mode for Transdermal Delivery of an Antidiabetic Drug. Drug Delivery, 20(1), 40–46.
Bragagni, M., Mennini, N., Maestrelli, F., Cirri, M., dan Mura, P., 2012. Comparative Study of Liposomes, Transfersomes and Ethosomes as Carriers for Improving Topical Delivery of Celecoxib. Drug Delivery, 19(7), 354–361.
Dave, V., Kumar, D., Lewis, S., dan Paliwal, S., 2010. Ethosome for Enhanced Transdermal Drug Delivery of Aceclofenac. International Journal of Drug Delivery, 2(1), 81–92.
Ermawati, D.E., dan Prilantari, H.U., 2019. Pengaruh Kombinasi Polimer Hidroksipropilmetilselulosa dan Natrium Karboksimetilselulosa terhadap Sifat Fisik Sediaan Matrix-based Patch Ibuprofen. Journal of Pharmaceutical Science and Clinical Research, 2(1), 109–119.
Fatmawaty, A., Nisa, M., Irmayani, dan Sunarti, 2017. Formulasi Patch Ekstrak Etanol Daun Murbei (Morus Alba L.) dengan Variasi Konsentrasi Polimer Polivinil Pirolidon dan Etil Selulosa. Journal of Pharmaceutical and Medicinal Sciences, 2(1), 17–20.
Fiume, M.M., Bergfeld, W.F., Belsito, D.V, Hill, R.A., Klaassen, C.D., Liebler, D., Jr, J.G.M., Shank, R.C., Slaga, T.J., Snyder, P.W., dan Andersen, F.A., 2012. Safety Assessment of Propylene Glycol, Tripropylene Glycol, and PPGs as Used in Cosmetics. International Journal of Toxicology, 31(2), 245S–260S.
Gaikwad, Kaveri A.B.S., dan Somwanshi, A.P., 2017. Ethanolic Vesicles: A Novel Approach to Enhance Transdermal Drug Delivery. Indo American Journal of Pharmaceutical Research, 7(1), 7440–7450.
Hendradi, N., Isnaeni, N., Fridayanti, A., dan Pujianti, E., 2011. Optimasi Sediaan Transdermal Patch Natrium Diklofenak Tipe Matriks. Jumal Farmasi Indonesia, 5(3), 112–119.
Hermanto, F.J., Lestari, F., Hermawati, C., dan Nurviana, V., 2019. Evaluasi Sediaan Patch Daun Handeulem (Graptophyllum griff L.) sebagai Penurun Panas. Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-Ilmu Keperawatan, Analis Kesehatan dan Farmasi, 19(2), 208–217.
Jaiswal, P.K., Kesharwani, S., Kesharwani, R., dan Patel, D.K., 2016. Ethosome: A New Technology Used as Topical and Transdermal Delivery System. Journal of Drug Delivery and Therapeutics, 6(3), 6–17.
Kumar, E., dan Patra, N., 2020. Development Characterization Optimization of Ethosome Containing Duloxetine for Transdermal Delivery. International Journal of Pharmaceutical Sciences and Research, 11(2), 652–659.
Limsuwan, T., Boonme, P., Khongkow, P., dan Amnuaikit, T., 2017. Ethosomes of Phenylethyl Resorcinol as Vesicular Delivery System for Skin Lightening Applications. BioMed Research International, 2(3), 1–12.
Liu, X., Liu, H., Liu, J., He, Z., Ding, C., Huang, G., Zhou, W., dan Zhou, L., 2011. Preparation of a Ligustrazine Ethosome Patch and its Evaluation in Vitro and in Vivo. International Journal of Nanomedicine, 6(1), 241–247.
Ma, H., Guo, D., Fan, Y., Wang, J., Cheng, J., dan Zhang, X., 2018. Paenol-Loaded Ethosomes as Transdermal Delivery Carriers: Design, Preparation and Evaluation. Molecule, 23(7), 1–15.
Mohanty, D., Mounika, A., Bakshi, V., Haque, A.M., dan Sahoo, K.C., 2018. Ethosomes: A Novel Approach for Transdermal Drug Delivery. International Journal of ChemTech Research, 11(8), 219–226.
Nagadevi, B., Kumar, K.S., Venkanna, P., dan Prabhakar, D., 2014. Formulation and Characterisation of Tizanidine Hydrochloride Loaded Ethosomes Patch. International Journal of Pharmacy and Pharmaceutical Sciences, 6(4), 199–205.
Nandure, H.P., Prashant, P., Prabhanjan, G., dan Vidya, L., 2013. Ethosome: A Novel Drug Carrier International Journal of Pharmaceutical Sciences and Allied Research (Impact Factor 3.181). International Journal of Pharmaceutical Research & Allied Sciences, 2(3), 18–30.
Niu, X.Q., Zhang, D.P., Bian, Q., Feng, X.F., Li, H., Rao, Y.F., Shen, Y.M., Geng, F.N., Yuan, A.R., Ying, X.Y., dan Gao, J.Q., 2019. Mechanism Investigation of Ethosomes Transdermal Permeation. International Journal of Pharmaceutics, 2(1), 1–13.
Nurmesa, A., Nurhabibah, dan Najihudin, A., 2019. Formulasi dan Evaluasi Stabilitas Fisik Patch Transdermal Alkaloid Nikotin Daun Tembakau (Nicotiana tobacum Linn) dengan Variasi Polimer dan Asam Oleat. Jurnal Penelitian Farmasi Herbal, 2(1), 1–8.
Pandey, V., Golhani, D., dan Shukla, R., 2015. Ethosomes: Versatile Vesicular Carriers for Efficient Transdermal Delivery of Therapeutic Agents. Drug Delivery, 22(8), 988–1002.
Patrekar, P.V, Inamdar, S.J., Mali, S.S., Mujib, M.T., Ahir, A.A., dan Hosmani A.H., 2015. Ethosomes As Novel Drug Delivery System: A Review. The Pharma Innovation Journal, 4(49), 10–21.
Prabhakara, P., Koland, M., Vijaynarayana, K., Harish N.M., Shankar G., Mohd G.A., Narayana C.R., dan Satyanarayana D., 2010. Preparation and Evaluation of Transdermal Patches of Papaverine Hydrochloride. International Journal of Research in Pharmaceutical Sciences, 1(3), 259–266.
Prasanthi, D., dan Lakshmi, P.K., 2012. Development of Ethosomes with Taguchi Robust Design-Based Studies for Transdermal Delivery of Alfuzosin Hydrochloride. International Current Pharmaceutical Journal, 1(11), 370–375.
Purnamasari, N., Alatas, F., dan Gozali, D., 2019. Formulasi dan Evaluasi Transdermal Patch Kalium Diklofenak. Jurnal Ilmiah Farmasi, 7(1), 43–48.
Rahim, F., Deviarny, C., Yenti, R., dan Ramadani, P., 2016. Formulasi Sediaan Patch Transdermal dari Rimpang Rumput Teki (Cyperus Rotundus L.) untuk Pengobatan Nyeri Sendi pada Tikus Putih Jantan. Scientia: Jurnal Farmasi Dan Kesehatan, 6(1), 1–6.
Rakesh, R., dan Anoop, K.R., 2012. Ethosomes for Transdermal and Topical Drug Delivery. International Journal of Pharmacy and Pharmaceutical Sciences, 4(3), 17–24.
Ramadhani, U.K.S., Djajadisastra, J., dan Iskandarsyah, I., 2017. Pengaruh Polimer dan Peningkat Penetrasi Terhadap Karakter Penetrasi Matriks Sediaan Patch Transdermal Karvedilol. Jurnal Ilmu Kefarmasian Indonesia, 15(2), 120–127.
Ramadon, D., dan Mun'im, A., 2016. Pemanfaatan Nanoteknologi dalam Sistem Penghantaran Obat Baru untuk Produk Bahan Alam. Jurnal Ilmu Kefarmasian Indonesia, 14(2), 118–127.
Salmannejad, F., Ghari, T., dan Toliyat, T., 2015. Formulation and Evaluation of Ethosomes for Transdermal Delivery of Clonazepam. International Journal of Biosciences, 6(5), 308–316.
Shen, S., Liu, S.Z., Zhang, Y.S., Du, M.B., Liang, A.H., Song, L.H., dan Ye, Z.G., 2015. Compound Antimalarial Ethosomal Cataplasm: Preparation, Evaluation, and Mechanism of Penetration Enhancement. International Journal of Nanomedicine, 10(1), 4239–4253.
Shukla, T., Verma, A., Upmanyu, N., Mishra, S. S., dan Shilpi, S., 2016. Development and Characterization of Clopidogrel-loaded Ethosomal Transdermal Patch for Antiplatelet Effect. Asian Journal of Pharmaceutics, 10(4), S680–S686.
Singh, A., dan Bali, A., 2016. Formulation and Characterization of Transdermal Patches for Controlled Delivery of Duloxetine Hydrochloride. Journal of Analytical Science and Technology, 7(1), 1–13.
Sultana, B., Rajak, P., Bhuyan, B., Patra, E., Baruah, A., dan Paul, D., 2018. Therapeutic Potential of Herbal Ethosome in Applied Nanotechnology. Saudi Journal of Medical and Pharmaceutical Sciences, 4(4), 443–454.
Suryani, Musnina, W.O.S., dan Anto, A.S., 2017. Optimasi Formula Matriks Patch Transdermal Nanopartikel Teofilin dengan Menggunakan Metode Simplex Lattice Design (SLD). Majalah Farmasi, Sains, dan Kesehatan, 3(1), 26–32.
Thadanki, M., dan Babu, A.K., 2015. Review on Ethosomes: A Novel Approach of Liposomes. International Journal of Phaarmacy and Life Sciences, 6(1), 4171–4176.
Wahid, A.A., Ravouru, N., dan Lakshman, S.R., 2011. Ethosomes: A Tool for Transdermal Drug Delivery, Current Trends in Biotechnology and Pharmacy, 5(1), 972–981.
Wusnah, Bahri, S., dan Hartono, D., 2016. Proses Pembuatan Bioetanol dari Kulit Pisang Kepok (Musa acuminata B.C) secara Fermentasi. Jurnal Teknologi Kimia Unimal, 5(1), 48–56.
Zahid, S. R., Upmanyu, N., Dangi, S., Ray, S. K., Jain, P., dan Parkhe, G., 2018. Ethosome: A Novel Vesicular Carrier for Transdermal Drug Delivery. Journal of Drug Delivery snd Therapeutics, 8(6), 318–326.
Authors
Andriani, R., Jubir, I., Aspadiah, V. and Fristiohady, A. (2021) “Review Jurnal: Pemanfaatan Etosom Sebagai Bentuk Sediaan Patch”, Farmasains : Jurnal Ilmiah Ilmu Kefarmasian, 8(1), pp. 45–57. doi: 10.22236/farmasains.v8i1.5386.
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