AKTIVITAS DIURETIK SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) FUROSEMID
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Issue
Vol. 4 No. 1 (2017)
Submitted
April 9, 2019
Published
April 29, 2017
Keywords:
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furosemide, SNEDDS, diuretic
Abstract
Furosemide is a diuretic having low solubility and low bioavailability thus the diuretic activity is not optimal. The purpose of this study was to determine the effect of furosemide SNEDDS formation to the diuretic activity. SNEDDS was made with a mixture of 66% tween 80, 26% propilene glycol, 8% oleic acid and furosemide 40 mg/mL. A total of 20 test animals were divided into 4 groups, namely the negative control 1 (CMC 0,5% suspension), negativ control 2 (a mixture of tween 80, propilene glycol and oleic acid), furosemid suspension and SNEDDS furosemid. Tests on the diuretic activity is done by measuring the volume of urine released for 6 hours.Furosemide SNEDDS could enhance the diuretic activity of furosemide.
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References
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Al-Mohizea, A.M., 2010. Influence of intestinal efflux pumps on the absorption and transport of furosemide. Saudi Pharm. J. SPJ 18, 97–101. doi:10.1016/j.jsps.2010.02.005
Bali, V; Ali, M and Ali, J, 2010, Study of Surfactant Combinations and Development of a Novel Nanoemulsion for Minimizing Variations in Bioavailability of Ezetimibe, Colloids. Surf. B Biointerfaces, 76, 410.
Balakumar, K., Raghavan, C.V., selvan, N.T., prasad, R.H., Abdu, S., 2013. Self nanoemulsifying drug delivery system (SNEDDS) of rosuvastatin calcium: design, formulation, bioavailability and pharmacokinetic evaluation. Colloids Surf. B Biointerfaces. 112, 337–343.
Berkó, S., Regdon Jr., G., Ducza, E., Falkay, G., ErÅ‘s, I., 2002. In vitro and in vivo study in rats of rectal suppositories containing furosemide. Eur. J. Pharm. Biopharm. 53, 311–315. doi:10.1016/S0939-6411(02)00005-X
Custodio, J.M., Wu, C.-Y., Benet, L.Z., 2008. Predicting drug disposition, absorption elimination btransporter interplay and the role of food on drug absorption. Adv. Drug Deliv. Rev. 60, 717–733. doi:10.1016/j.addr.2007.08.043
Davis, S.S., 2005, Formulations Strategies for Absorpstion Window, Drug Discov.Today, 10, 249–257
Doh, H.-J., Jung, Y., Balakrishnan, P., Cho, H.-J., Kim, D.-D., 2013. A novel lipid nanoemulsion system for improved permeation of granisetron. Colloids Surf. B Biointerfaces 101, 475–480. doi:10.1016/j.colsurfb.2012.07.019
Gupta, S., Chavhan, S., Sawant, K.K., 2011. Self-nanoemulsifying drug delivery system for adefovir dipivoxil: Design, characterization, in vitro and ex vivo evaluation. Colloids Surf. Physicochem. Eng. Asp. 392, 145–155.
Guyton, A. C., Hall, J. E. 2006. Textbook of Medical Physiology. Edisi XI. Elvesier inc. Philadelphia.
Makadia, M.H.A., Bhatt, M.A.Y., Parmar, M.R.B., Paun, M.J.S., Tank, D.H.M., 2013. Self-nano Emulsifying Drug Delivery System (SNEDDS): Future Aspects. Int. J. Technol. 3.
Mohsin, K., Shahba, A.A., Alanazi, F.K., 2012. Lipid Based Self Emulsifying Formulations for Poorly Water Soluble Drugs-An Excellent Opportunity. ResearchGate 46, 88–96.
Nazzal, S., Smalyukh, I.I., Lavrentovich, O.D., Khan, M.A., 2002. Preparation and in vitro characterization of a eutectic based semisolid self-nanoemulsified drug delivery system (SNEDDS) of ubiquinone: mechanism and progress of emulsion formation. Int. J. Pharm. 235, 247–265.
O'Driscoll, C.M., 2002. Lipid-based formulations for intestinal lymphatic delivery. Eur. J. Pharm. Sci. Off. J. Eur. Fed. Pharm. Sci. 15, 405–415.
Patel, J., Kevin, G., Patel, A., Raval, M., Sheth, N., 2011. Design and development of a self-nanoemulsifying drug delivery system for telmisartan for oral drug delivery. Int. J. Pharm. Investig. 1, 112–118. doi:10.4103/2230-973X.82431
Porter, C.J.H., Pouton, C.W., Cuine, J.F., Charman, W.N., 2008. Enhancing intestinal drug solubilisation using lipid-based delivery systems. Adv. Drug Deliv. Rev. 60, 673–691. doi:10.1016/j.addr.2007.10.014
Pritchett, K.R. and B.F. Corning. 2004. Biology and Medicine of Rats.www.ivis.org/ advances/Reuter/coming/ivis.pdf last update 12 Maret 2006
Prabhakar, K., Afzal, S.M., Surender, G., Kishan, V., 2013. Tween 80 containing lipid nanoemulsions for delivery of indinavir to brain. Acta Pharm. Sin. B 3, 345–353. doi:10.1016/j.apsb.2013.08.001
Rajesh, B.., Reddy, T.., Srikanth, G., Mallikarjun, V., Nivethithai, P., 2010. Lipid Based Self-emulsifying Drug Delivery System (SEDDS) for Poorly water-soluble Drugs: A Review. JGlob Pharma Technol 2, 47–55.
Wahyuningsih, I., Sugiyanto, Yuswanto, A., Martien, R., 2016, Formulasi Self-Nano Emulsifying Drug Delivery System (SNEDDS) Furosemid: Studi Parameter Fisikokimia, Bioavailabilitas, Efek Diuretik dan Toksisitas, Laporan Penelitian.
Wang, L., Dong, J., Chen, J., Eastoe, J., Li, X., 2009. Design and optimization of a new self-nanoemulsifying drug delivery system. J. Colloid Interface Sci. 330, 443–448. doi:10.1016/j.jcis.2008.10.077
Xi, J., Qi, C., Chak, K.C., Zhao, Y.M., Geng, N.W., Jia, B.S., Yi, T.W., Henry, H.Y.T., Ying, Z., Formulation Development and Bioavailability Evaluation of a Self-Nanoemulsified Drug Delivery System of Oleanolic Acid, American Association of Pharmaceutical Scientist Thecnology, 2009. 10(1): 172-182.
Yadav, P., Yadav, E., Verma, A., Amin, S., 2014. In vitro characterization and pharmacodynamic evaluation of furosemide loaded self nano emulsifying drug delivery systems (SNEDDS). J. Pharm. Investig. 44, 443–453. doi:10.1007/s40005-014-0138-z
Authors
wahyuningsih, iis, sugiyanto, sugiyanto, Yuswanto, A. and martien, ronny (2017) “AKTIVITAS DIURETIK SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) FUROSEMID”, Farmasains : Jurnal Ilmiah Ilmu Kefarmasian, 4(1), pp. 33–38. doi: 10.22236/farmasains.v4i1.3360.
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