UJI SITOTOKSIK EKSTRAK ETANOL 50% DAUN KITOLOD (Isotoma longiflora (L.) Presl.) TERHADAP SEL KANKER SERVIKS (Ca Ski Cell Line) SECARA IN- VITRO

  • Aprilita rina yanti Fakultas Ilmu-ilmu Kesehatan Universitas Esa Unggul

Abstract

Kitolod (Isotoma longiflora (L.) Presl.) Is a traditional medicinal plant which is efficacious as anticancer. Empirically kitolod had been used  by Indonesian people for the treatment of cancer, but this remains to be proven scientifically through research. The objective of this research was to determine the cytotoxic activity of 50% Ethanol Extract of Kitolod leaves (Isotoma longiflora (L.) Presl) at a concentration of 25 mg / mL, 50 mg / mL, 75 mg / mL, and 125 mg / mL against cervical cancer cells (Ca Ski Cell Line) in vitro assay using red natural methods.Results of Cytotoxic assay  shows that  IC50 values 50% Ethanol Extract of Kitolod leaves (Isotoma longiflora (L.) Presl) in Ca Ski Cell Line  is  55.78 ug / mL. Ethanol extract  at  concentration of 25 mg / mL, 50 mg / mL, 75 mg / mL, and 125 mg / mL have cytotoxic effecst against cervical cancer cells (Ca Ski Cell Line) and extract at a concentration of 125 ug / mL indicates the largest percentage of cell death.

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Published
2017-01-09
How to Cite
YANTI, Aprilita rina. UJI SITOTOKSIK EKSTRAK ETANOL 50% DAUN KITOLOD (Isotoma longiflora (L.) Presl.) TERHADAP SEL KANKER SERVIKS (Ca Ski Cell Line) SECARA IN- VITRO. Farmasains : Jurnal Ilmiah Ilmu-Ilmu Kefarmasian, [S.l.], v. 3, n. 1, p. 7-12, jan. 2017. ISSN 2086-6968. Available at: <http://journal.uhamka.ac.id/index.php/farmasains/article/view/127>. Date accessed: 26 sep. 2017.
Section
Articles

Keywords

Kitolod (Isotoma longiflora (L.) Presl.), cytotoxic, , Ca ki Cell line, natural red